Development and test of an as­so­ciated vaccine Welshicolisan against gastrointestinal bac­terioses of pigs

Abstract

The purpose. To develop efficient associated vaccine against the most spread bacterioses of pigs. Methods. Microbiological, biological, serological, statistical. Microscopic studies are carried out, features of growth of cultures of isolates-originators of bacteriemic diseases are studied. Results. Probes have confirmed antigenic activity of the vaccine as at inoculated rabbits titres of specific antibodies were authentically enlarged. The adjuvanticity of the specimen ensured preservation of 83,3% of the vaccinated white mice after infestation with originators C. Perfringens and E. coli. Immunobiological reorganization of an organism of the vaccinated pigs is confirmed by titres of specific agglutinins, and economic efficiency — by preserved expenditures in pig-breeding equipments at rate of 240 – 320 thousand hrn for a year. Conclusions. Economically efficient antigen-active highly-immunifacient vaccine Welshicolisan against anaerobic dysentery, contagious enterotoxaemia, hydropic illness, and colibacteriosis of animals is developed.